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Dr. Swati Palit Deb

Dr Deb's publications.

  1. Singh S, Vaughan CA., Rabender C., Mikkelsen R., Deb S and Deb SP. DNA replication in progenitor cells and epithelial regeneration after lung injury requires the oncoprotein MDM2 JCI Insight. 2019 (ahead of print) PubMed PMID:31527309 DOI: DNA replication in progenitor cells

  2. Singh S, Vaughan CA, Frum RA, Grossman SR, Deb S, Deb SP. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication J Clin Invest. 2017; 127:1839-1855. pii: 87724. doi: 10.1172/JCI87724. (highlighted by J Clin Invest in twitter, @jclinicalinvest and in the journal websiteEureka Alert: Massey scientists achieve breakthrough.).

  3. Vaughan CA, Singh S, Grossman SR, Windle B, Deb SP, Deb S. Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells. Mol Oncol. 2017 Apr 18. doi: 10.1002/1878-0261.12068.

  4. Frum RA, Singh S, Vaughan C, Mukhopadhyay ND, Grossman SR, Windle B, Deb S, Deb SP. The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing. Nucleic acids research. 2014;42(2):926-940. Epub 2013/10/29. doi: 10.1093/nar/gkt944. PubMed PMID: 24163099; PubMed Central PMCID: PMC3902934

  5. Singh S, Ramamoorthy, M, Vaughan CA, Windle B, Yeudall WA, Deb S, Deb SP. Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element -1 silencing transcription factor (REST) conferring a survival advantage to cancer cells. Cell Death Differ. 2013. 20: 558-566. PMCID: PMC3595481

  6. Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman S, Deb SP and Deb S. Gain-of function activity of mutant p53 in lung cancer through up-regulation of receptor protein tyrosine kinase Axl. Genes & Cancer 2012. 3:491-502. PMCID: PMC3527987

  7. Zhou R, Frum R, Deb S, Deb SP. The growth arrest function of the human oncoprotein mouse double minute-2 is disabled by downstream mutation in cancer cells. Cancer Res. 2005;65(5):1839-1848. PubMed PMID: 15753382.

  8. Brown DR, Deb S, Munoz RM, Subler MA, Deb SP. The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein. Mol Cell Biol. 1993;13(11):6849-6857. PubMed PMID: 8413278.

  9. Leng P, Brown DR, Shivakumar CV, Deb S, Deb SP. N-terminal 130 amino acids of MDM2 are sufficient to inhibit p53-mediated transcriptional activation. Oncogene. 1995;10(7):1275-1282. PubMed PMID: 7731677.

Complete List of Published Work:here